Entry in to the WHI. Participants have been categorized into “never smokers,” “former smokers,” and “current smokers” as outlined by their smoking history. Levels of alcohol intake (g/d) and total power intake (kcal/d) were also calculated in the FFQ. Physique weight and height have been measured at baseline entry in to the WHI, and BMI was calculated as body weight (kg) divided by height (m) squared. The amount of physical activity in metabolic equivalent hours per week was estimated around the basis of selfreported duration of different kinds of exercising, weighted by their intensity levels. Measurement of peripheral leukocyte TLs. The measurement of TL has been described elsewhere (14). In brief, we applied the method proposed by O allaghan et al. (21) in a highthroughput, 384well format using Applied Biosystems 7900HT PCR System (Applied Biosystems by Life Technologies Corporation). Imply TL per chromosome was calculated together with the use with the following formula: (TL/copies of diploid 908 Song et al.ResultsA total of 4029 WHI participants have been integrated in this study. We retained 3 factors in the exploratory issue evaluation that together accounted for 85.six on the total variance in the original 23 variables (Supplemental Table 1). The very first aspect accounted primarily for SMSFAs [including butyric (4:0), hexanoic (six:0), octanoic (8:0), decanoic (10:0), and lauric acid (12:0)]. The second factor primarily represented plant supply FAs [including primarily arachidic (20:0) and gadoleic acid (20:1), also with reasonably large issue loadings of behenic (22:0), oleic (18:1), linoleic (18:2), and linolenic acid (18:three)]. The third issue virtually exclusively accounted for marinesource FAs, including EPA (20:5n23), docosapentaenoic acid (DPA, 22:5n23), and DHA (22:6n23). Participantscharacteristics based on quartiles of TL are summarized in Table 1. Participants with shorter TLTABLE 1 Traits of the participants by quartiles of peripheral leukocyte telomere length inside a subsample of postmenopausal ladies from the WHILeukocyte telomere length Quartile 1 (n = 1007) Quartile two (n = 1007) Quartile 3 (n = 1007) Quartile 4 (n = 1008) Median telomere length (IQR), kb Age, y Raceethnicity, White Black Hispanic Asian/Pacific Islander Total energy intake, kcal/d BMI, kg/m2 Smoking, Never ever Former Current Alcohol intake, g/d Physical activity, METh/wk Total fat intake, of energy SFAs, of power MUFAs, of power PUFAs, of energy 2.60 (two.19.87) 63.4 six 7.2 55.2 28.two eight.3 8.two 1580 six 890 29.5 six 6.five 51.2 40.9 8.0 four.6-Bromo-4-chloro-1H-indole Chemscene 3 six 12.2 11.1 six 12.Formula of 1075198-30-9 9 32.PMID:23795974 0 six 9.1 ten.4 six three.3 12.1 six three.9 six.8 6 two.five three.53 (three.32.73) 63.1 six 7.1 55.5 25.0 11.three 8.1 1630 six 950 29.three six six.eight 54.1 38.4 7.5 3.1 6 7.two 12.3 six 14.two 31.2 6 eight.6 ten.2 six 3.three 11.8 six three.6 six.6 6 2.2 4.32 (4.12.54) 62.2 six 7.1 49.9 30.5 12.7 six.9 1580 6 900 29.7 six six.8 55.two 37.three 7.4 three.1 6 8.3 11.6 six 13.3 31.7 6 8.six ten.three 6 3.1 12.1 6 3.6 six.8 six two.4 five.57 (five.14.30) 61.5 six 6.7 40.0 36.7 16.0 7.three 1570 6 830 29.5 six 6.8 55.0 38.5 6.5 2.7 six 6.7 11.two 6 14.0 31.six six 8.5 ten.1 6 three.1 12.1 six three.five 6.8 6 2.5 P,0.001 ,0.0.43 0.55 0.,0.001 0.23 0.22 0.17 0.23 0.1 Continuous variables are shown as indicates 6 SDs and categorical variables are shown as percentages. METh, metabolic equivalent hours; WHI, Females Wellness Initiative. two P values are determined by ANOVA for continuous variables and on chisquare test for categorical variables.tended to be white, older, and consumed extra alcohol. Everyday power intake did not differ considerably across quartiles of TL. In comparison to wome.