Nectivity in schizophrenia. Am J Psychiatry 169(10):1092?099. 19. Deco G, et al. (2013) Resting-state functional connectivity emerges from structurally and dynamically shaped slow linear fluctuations. J Neurosci 33(27):11239?1252. 20. Wong KF, Wang XJ (2006) A recurrent network mechanism of time integration in perceptual decisions. J Neurosci 26(four):1314?328. 21. Mitra PP, Pesaran B (1999) Analysis of dynamic brain imaging information. Biophys J 76(two): 691?08. 22. Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE (2013) Methods toward optimizing motion artifact removal in functional connectivity MRI; a reply to Carp. Neuroimage 76:439?41. 23. Gotts SJ, et al. (2013) The perils of global signal regression for group comparisons: A case study of autism spectrum problems. Front Hum Neurosci 7:356.inferences. Lastly, this study highlights the achievable neurobiological importance of global/local BOLD signal variance alterations in SCZ, which may well relate to synaptic coupling disruptions that could possibly be amenable to pharmacological intervention. Experimental ProceduresParticipants. For complete procedures with regards to topic choice, inclusion/exclusion criteria, group matching, medication, and symptom analyses, see SI Appendix. Neuroimaging. For a full description of acquisition, processing and all neuroimaging analyses see SI Appendix. Computational Modeling. We applied a validated computational model of resting-state functional connectivity (19), extending a nearby circuit model (20) to incorporate biologically plausible mechanisms for BOLD signal fluctuations.2356229-58-6 Price Complete modeling facts are presented inside the SI Appendix. ACKNOWLEDGMENTS. We thank Dr. David Van Essen for helpful comments through manuscript preparation; Dr. Francis Song for help with implementing anatomical connectivity in to the model; and Dr. Vince Calhoun for assistance using the publicly obtainable Center for Biomedical Research Excellence dataset. Economic assistance was provided by National Institutes of Wellness Grants DP50D012109-02 [to A.A., PI (principal investigator)], MH080912 (to D.C.G., PI), MH096801 (to M.W.C., PI), and MH43775, MH077945, and MH074797 (to G.D.P., PI); National Institute on Alcohol Abuse and Alcoholism Grant 2P50AA012870-11 (to J.H.K., PI); the Fulbright Foundation (A.S.); the National Alliance for Investigation on Schizophrenia and Depression Young Investigator Award (to A.A., PI); Grant R01-MH062349 (to J.D.M. and X.-J.W.); and National Institutes of Overall health Grant T32GM 007205 (to G.J.Y.).24. Andreasen NC (1997) The role with the thalamus in schizophrenia. Can J Psychiatry 42(1):27?3. 25. Goldman-Rakic PS (1991) Prefrontal cortical dysfunction in schizophrenia: The relevance of functioning memory. Psychopathology along with the Brain, eds Carroll BJ, Barrett JE (Raven Press, New York), pp 1?3.448-61-3 Purity 26.PMID:24120168 Cohen AL, et al. (2008) Defining functional regions in individual human brains applying resting functional connectivity MRI. Neuroimage 41(1):45?7. 27. Hagmann P, et al. (2008) Mapping the structural core of human cerebral cortex. PLoS Biol six(7):e159. 28. Murphy K, Birn RM, Handwerker DA, Jones TB, Bandettini PA (2009) The impact of international signal regression on resting state correlations: Are anti-correlated networks introduced? Neuroimage 44(three):893?05. 29. Whitfield-Gabrieli S, et al. (2009) Hyperactivity and hyperconnectivity from the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proc Natl Acad Sci USA 106(4):1279?284. 30. Baker JT, et.